Product Data Sheet
Lazabemide hydrochloride
Catalog No. A79098
Lazabemide hydrochloride is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 0.03 μM, demonstrating minimal activity against MAO-A (IC50 > 100 μM). At elevated concentrations, it inhibits monoamine uptake, with IC50 values of 86 μM for noradrenaline, 123 μM for serotonin, and >500 μM for dopamine. This compound is primarily used in research related to Parkinson's and Alzheimer's diseases, offering insights into the management of neurodegenerative disorders.
Chemical Information
| Catalog Num | A79098 |
|---|---|
| M. Wt | 236.10 |
| Formula | C8H11Cl2N3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 103878-83-7 |
| Synonyms | Ro 19-6327 hydrochloride |
| SMILES | O=C(C1=NC=C(Cl)C=C1)NCCN.[H]Cl |
Biological Activity
| Description | Lazabemide hydrochloride is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 0.03 μM, demonstrating minimal activity against MAO-A (IC50 > 100 μM). At elevated concentrations, it inhibits monoamine uptake, with IC50 values of 86 μM for noradrenaline, 123 μM for serotonin, and >500 μM for dopamine. This compound is primarily used in research related to Parkinson's and Alzheimer's diseases, offering insights into the management of neurodegenerative disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
