Product Data Sheet
ASR-490
Catalog No. A79148
ASR-490 is a selective Notch1 inhibitor that effectively reduces the viability of HCT116 and SW620 cancer cell lines by downregulating Notch1 signaling pathways. This compound successfully impedes tumor growth in both control cells and Notch1-overexpressing HCT116 transfectants. In vivo studies demonstrate that ASR-490 significantly inhibits tumor growth in xenograft models, highlighting its potential as a therapeutic agent in cancer research.
Chemical Information
| Catalog Num | A79148 |
|---|---|
| M. Wt | 575.69 |
| Formula | C34H41NO7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2690312-67-3 |
| Synonyms | |
| SMILES | C[C@]([C@](CC[C@@]12C)([H])[C@@]([C@]1([H])CC[C@]2([H])[C@@H]([C@@](OC3=O)([H])CC(C)=C3CO)C)([H])C4)(C5=O)[C@@]6([C@H](C=C5)OC(C7=CC=CC=N7)=O)[C@]4([H])O6 |
Biological Activity
| Description | ASR-490 is a selective Notch1 inhibitor that effectively reduces the viability of HCT116 and SW620 cancer cell lines by downregulating Notch1 signaling pathways. This compound successfully impedes tumor growth in both control cells and Notch1-overexpressing HCT116 transfectants. In vivo studies demonstrate that ASR-490 significantly inhibits tumor growth in xenograft models, highlighting its potential as a therapeutic agent in cancer research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
