Product Data Sheet
Wy-45494 hydrochloride
Catalog No. A79207
Wy-45494 hydrochloride is a potent serotonin transporter inhibitor deriving from the selective norepinephrine and serotonin reuptake inhibitor venlafaxine, primarily formed via cytochrome P450 CYP3A4 metabolism. This compound demonstrates significant biological activity by inhibiting norepinephrine and serotonin reuptake, with IC50 values of 4.7 μM and 1.6 μM, respectively, in rat synaptosomal preparations. In animal studies, it effectively reverses reserpine-induced hypothermia in mice, establishing its potential utility in research related to mood disorders and neurotransmitter regulation.
Chemical Information
| Catalog Num | A79207 |
|---|---|
| M. Wt | 299.84 |
| Formula | C16H26ClNO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 93413-90-2 |
| Synonyms | N-Desmethyl Venlafaxine hydrochloride; Wy 45494 |
| SMILES | OC1(C(C2=CC=C(OC)C=C2)CNC)CCCCC1.[H]Cl |
Biological Activity
| Description | Wy-45494 hydrochloride is a potent serotonin transporter inhibitor deriving from the selective norepinephrine and serotonin reuptake inhibitor venlafaxine, primarily formed via cytochrome P450 CYP3A4 metabolism. This compound demonstrates significant biological activity by inhibiting norepinephrine and serotonin reuptake, with IC50 values of 4.7 μM and 1.6 μM, respectively, in rat synaptosomal preparations. In animal studies, it effectively reverses reserpine-induced hypothermia in mice, establishing its potential utility in research related to mood disorders and neurotransmitter regulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
