Product Data Sheet
Siramesine fumarate
Catalog No. A79289
Siramesine fumarate is a potent sigma-2 receptor agonist with a subnanomolar affinity for sigma-2 receptors (IC50 = 0.12 nM) and a 140-fold selectivity over sigma-1 receptors (IC50 = 17 nM). This compound induces cell death through the destabilization of mitochondria without affecting lysosomes. Siramesine fumarate has demonstrated significant anti-cancer activity, making it a valuable tool for research in cancer therapeutics and the study of sigma receptor biology.
Chemical Information
| Catalog Num | A79289 |
|---|---|
| M. Wt | 570.65 |
| Formula | C34H35FN2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 163630-79-3 |
| Synonyms | LU-28-179 fumarate |
| SMILES | FC1=CC=C(C=C1)N2C=C(C3=C2C=CC=C3)CCCCN4CCC5(OCC6=C5C=CC=C6)CC4.O=C(/C=C/C(O)=O)O |
Biological Activity
| Description | Siramesine fumarate is a potent sigma-2 receptor agonist with a subnanomolar affinity for sigma-2 receptors (IC50 = 0.12 nM) and a 140-fold selectivity over sigma-1 receptors (IC50 = 17 nM). This compound induces cell death through the destabilization of mitochondria without affecting lysosomes. Siramesine fumarate has demonstrated significant anti-cancer activity, making it a valuable tool for research in cancer therapeutics and the study of sigma receptor biology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
