Product Data Sheet
Minzasolmin
Catalog No. A79407
Minzasolmin (UCB0599; (R)-NPT200-11) is an orally bioavailable compound that functions as an α-synuclein oligomerization inhibitor. By selectively binding to misfolded α-synuclein intermediates, it disrupts aggregation and fibril formation, thereby stabilizing their conformation. This mechanism effectively reduces the formation of pathological oligomers and blocks neurotoxic signaling, contributing to decreased α-synuclein accumulation in the brain. Preclinical studies demonstrated that Minzasolmin significantly improved motor deficits and reduced neuroinflammation, as well as α-synuclein-related pathology in transgenic mouse models.
Chemical Information
| Catalog Num | A79407 |
|---|---|
| M. Wt | 425.59 |
| Formula | C23H31N5OS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1802518-92-8 |
| Synonyms | UCB0599; (R)-NPT200-11 |
| SMILES | O=C(C1=CN=C(N2CCN(CC2)C)S1)N[C@H](CCCC)CC3=CNC4=CC=CC=C34 |
Biological Activity
| Description | Minzasolmin (UCB0599; (R)-NPT200-11) is an orally bioavailable compound that functions as an α-synuclein oligomerization inhibitor. By selectively binding to misfolded α-synuclein intermediates, it disrupts aggregation and fibril formation, thereby stabilizing their conformation. This mechanism effectively reduces the formation of pathological oligomers and blocks neurotoxic signaling, contributing to decreased α-synuclein accumulation in the brain. Preclinical studies demonstrated that Minzasolmin significantly improved motor deficits and reduced neuroinflammation, as well as α-synuclein-related pathology in transgenic mouse models. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
