Product Data Sheet
NAB2
Catalog No. A79414
NAB2 is a neuroprotective agent that specifically targets the small GTPase Rab1a. By selectively binding to the GDP-bound form of Rab1a, NAB2 enhances Rab1a expression, thereby protecting various cell types from α-synuclein toxicity. This compound plays a critical role in regulating ER-to-Golgi trafficking and modulates endosomal trafficking of the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 also promotes the ubiquitination of related proteins in a Nedd4-dependent manner, effectively addressing α-synuclein-associated trafficking deficits linked to early-onset Parkinson's disease.
Chemical Information
| Catalog Num | A79414 |
|---|---|
| M. Wt | 389.88 |
| Formula | C23H20ClN3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1504588-00-4 |
| Synonyms | |
| SMILES | CC1=C(C=C(C)C=C1)N2C3=CC=C(C(NCC4=C(C=CC=C4)Cl)=O)C=C3N=C2 |
Biological Activity
| Description | NAB2 is a neuroprotective agent that specifically targets the small GTPase Rab1a. By selectively binding to the GDP-bound form of Rab1a, NAB2 enhances Rab1a expression, thereby protecting various cell types from α-synuclein toxicity. This compound plays a critical role in regulating ER-to-Golgi trafficking and modulates endosomal trafficking of the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 also promotes the ubiquitination of related proteins in a Nedd4-dependent manner, effectively addressing α-synuclein-associated trafficking deficits linked to early-onset Parkinson's disease. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
