Product Data Sheet
HUP-55
Catalog No. A79427
HUP-55 is a potent prolyl endopeptidase inhibitor with an IC50 of 5 nM. This compound significantly reduces α-synuclein dimerization in Neuro2a cells and induces autophagy in HEK293 cells. Additionally, HUP-55 effectively decreases reactive oxygen species (ROS) production in SH-SY5Y cells when administered at 10 μM. In vivo studies reveal that HUP-55 enhances motor function and reduces harmful oligomer levels of α-synuclein in the striatum in a mouse model of Parkinson’s disease, demonstrating its potential in neuroprotective research applications.
Chemical Information
| Catalog Num | A79427 |
|---|---|
| M. Wt | 295.38 |
| Formula | C18H21N3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3006795-68-9 |
| Synonyms | |
| SMILES | CC1=C(N2[C@@H](CCC2)C#N)OC(CCCC3=CC=CC=C3)=N1 |
Biological Activity
| Description | HUP-55 is a potent prolyl endopeptidase inhibitor with an IC50 of 5 nM. This compound significantly reduces α-synuclein dimerization in Neuro2a cells and induces autophagy in HEK293 cells. Additionally, HUP-55 effectively decreases reactive oxygen species (ROS) production in SH-SY5Y cells when administered at 10 μM. In vivo studies reveal that HUP-55 enhances motor function and reduces harmful oligomer levels of α-synuclein in the striatum in a mouse model of Parkinson’s disease, demonstrating its potential in neuroprotective research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
