Product Data Sheet
JP-163-16
Catalog No. A79587
JP-163-16 is a RelA/p65 PROTAC degrader that facilitates the selective degradation of RelA/p65 via the proteasome pathway. By inhibiting the NF-κB signaling pathway, JP-163-16 promotes apoptosis in cells, making it a valuable tool for investigating RelA/p65-dependent tumors, including chronic lymphocytic leukemia (CLL). This compound is instrumental for studies aimed at understanding the role of NF-κB in cancer progression and therapeutic resistance.
Chemical Information
| Catalog Num | A79587 |
|---|---|
| M. Wt | 777.86 |
| Formula | C42H47N7O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3100147-70-1 |
| Synonyms | |
| SMILES | O=C(NC1=CC=C(NC(CCCOC2=C(OC)C=C3C(N=C[C@@](CCC4)([H])N4C3=O)=C2)=O)C=C1)CCCCCNC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O |
Biological Activity
| Description | JP-163-16 is a RelA/p65 PROTAC degrader that facilitates the selective degradation of RelA/p65 via the proteasome pathway. By inhibiting the NF-κB signaling pathway, JP-163-16 promotes apoptosis in cells, making it a valuable tool for investigating RelA/p65-dependent tumors, including chronic lymphocytic leukemia (CLL). This compound is instrumental for studies aimed at understanding the role of NF-κB in cancer progression and therapeutic resistance. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
