Product Data Sheet
AV457
Catalog No. A79726
AV457 is a potent and selective inhibitor of the mTOR pathway, exhibiting an IC50 value of 0.54 µM. This compound has demonstrated efficacy in reducing cyst growth in organoids derived from polycystic kidney disease (PKD). Additionally, AV457 effectively lowers the protein expression levels of P-S6 and P-P70S6, while leaving P-AKT levels unchanged, making it a valuable tool for investigating mTOR-related signaling in various biological contexts.
Chemical Information
| Catalog Num | A79726 |
|---|---|
| M. Wt | 1065.36 |
| Formula | C55H88N2O16S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2713387-11-0 |
| Synonyms | |
| SMILES | O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)NS(CCOCCOC)(=O)=O)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](O)CC4)OC)C)=O)=O |
Biological Activity
| Description | AV457 is a potent and selective inhibitor of the mTOR pathway, exhibiting an IC50 value of 0.54 µM. This compound has demonstrated efficacy in reducing cyst growth in organoids derived from polycystic kidney disease (PKD). Additionally, AV457 effectively lowers the protein expression levels of P-S6 and P-P70S6, while leaving P-AKT levels unchanged, making it a valuable tool for investigating mTOR-related signaling in various biological contexts. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
