Product Data Sheet
PD-M6
Catalog No. A79733
PD-M6 is an mTOR-targeted PROTAC degrader that facilitates the ubiquitination and subsequent degradation of mTOR, exhibiting a DC50 of 4.8 μM. This compound has demonstrated potent anti-proliferative effects on HeLa, MCF-7, and HepG2 cancer cell lines, with IC50 values of 11.3, 2.58, and 3.23 μM, respectively. Additionally, PD-M6 induces autophagy and specifically promotes the degradation of LAMTOR1, a pivotal component of the mTOR signaling pathway, suggesting its utility for investigating mTOR-related biological processes in cancer research.
Chemical Information
| Catalog Num | A79733 |
|---|---|
| M. Wt | 621.69 |
| Formula | C30H39N9O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3058330-82-5 |
| Synonyms | |
| SMILES | O=C1N(C2CCC(NC2=O)=O)C(C3=CC=CC(NCCCCCCNC4=NC(N5CCOCC5)=NC(N6CCOCC6)=N4)=C13)=O |
Biological Activity
| Description | PD-M6 is an mTOR-targeted PROTAC degrader that facilitates the ubiquitination and subsequent degradation of mTOR, exhibiting a DC50 of 4.8 μM. This compound has demonstrated potent anti-proliferative effects on HeLa, MCF-7, and HepG2 cancer cell lines, with IC50 values of 11.3, 2.58, and 3.23 μM, respectively. Additionally, PD-M6 induces autophagy and specifically promotes the degradation of LAMTOR1, a pivotal component of the mTOR signaling pathway, suggesting its utility for investigating mTOR-related biological processes in cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
