Product Data Sheet
PF-06843195
Catalog No. A79789
PF-06843195 is a highly selective inhibitor of the PI3Kα isoform, exhibiting an IC50 of 18 nM in Rat1 fibroblasts. With kinase inhibition constants (Kis) of less than 0.018 nM and 0.28 nM for PI3Kα and PI3Kδ respectively, this compound effectively suppresses the PI3K/mTOR signaling pathway. PF-06843195 demonstrates significant antitumor efficacy, making it a valuable tool for research applications targeting cancer biology and therapeutic development.
Chemical Information
| Catalog Num | A79789 |
|---|---|
| M. Wt | 498.46 |
| Formula | C20H25F3N8O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2067281-51-8 |
| Synonyms | |
| SMILES | OC[C@]1(CN(CC1)C(OCC(F)F)=O)NC2=NC(N3CCOCC3)=NC(C4=CN=C(N)N=C4)=C2F |
Biological Activity
| Description | PF-06843195 is a highly selective inhibitor of the PI3Kα isoform, exhibiting an IC50 of 18 nM in Rat1 fibroblasts. With kinase inhibition constants (Kis) of less than 0.018 nM and 0.28 nM for PI3Kα and PI3Kδ respectively, this compound effectively suppresses the PI3K/mTOR signaling pathway. PF-06843195 demonstrates significant antitumor efficacy, making it a valuable tool for research applications targeting cancer biology and therapeutic development. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
