Product Data Sheet
PI3K-IN-2
Catalog No. A79813
PI3K-IN-2 is a potent and orally bioavailable inhibitor of PI3Kβ and PI3Kδ, exhibiting IC50 values of 7.1 nM and 8.6 nM, respectively. This compound demonstrates excellent selectivity over other isoforms, such as PI3Kσ and PI3Kγ, with IC50 values of 13 nM and 190 nM. Due to its specificity and potency, PI3K-IN-2 is suitable for research applications focusing on cancer, inflammation, and other diseases associated with dysregulated PI3K signaling pathways.
Chemical Information
| Catalog Num | A79813 |
|---|---|
| M. Wt | 525.54 |
| Formula | C28H29F2N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1403458-28-5 |
| Synonyms | |
| SMILES | O=C1C=C(N2CCOCC2)OC3=C([C@@H]4N(C5=CC(F)=CC(F)=C5)CCC4)C=C(C(N6CCOCC6)=O)C=C13 |
Biological Activity
| Description | PI3K-IN-2 is a potent and orally bioavailable inhibitor of PI3Kβ and PI3Kδ, exhibiting IC50 values of 7.1 nM and 8.6 nM, respectively. This compound demonstrates excellent selectivity over other isoforms, such as PI3Kσ and PI3Kγ, with IC50 values of 13 nM and 190 nM. Due to its specificity and potency, PI3K-IN-2 is suitable for research applications focusing on cancer, inflammation, and other diseases associated with dysregulated PI3K signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
