Product Data Sheet
VH285-PEG4-C4-Cl
Catalog No. A79938
VH285-PEG4-C4-Cl is an E3 ligase ligand-linker conjugate that employs a halogenated connector within its 16-atom length linker. This compound combines the VH285-based VHL ligand with an alkyl/ether-based linker, demonstrating high efficacy as a degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl achieves approximately 90% degradation of GFP-HaloTag7 at a concentration of 625 nM and exhibits an IC50 value of 0.54 μM for binding to VHL. This compound is ideal for researchers investigating targeted protein degradation and E3 ligase interactions.
Chemical Information
| Catalog Num | A79938 |
|---|---|
| M. Wt | 799.42 |
| Formula | C41H55ClN4O8S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1799506-07-2 |
| Synonyms | HaloPROTAC 3 |
| SMILES | CC(N=CS1)=C1C2=CC(OCCOCCOCCOCCCCCCCl)=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)=O)C=C2 |
Biological Activity
| Description | VH285-PEG4-C4-Cl is an E3 ligase ligand-linker conjugate that employs a halogenated connector within its 16-atom length linker. This compound combines the VH285-based VHL ligand with an alkyl/ether-based linker, demonstrating high efficacy as a degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl achieves approximately 90% degradation of GFP-HaloTag7 at a concentration of 625 nM and exhibits an IC50 value of 0.54 μM for binding to VHL. This compound is ideal for researchers investigating targeted protein degradation and E3 ligase interactions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
