Product Data Sheet
Pomalidomide-PEG1-C2-N3
Catalog No. A79945
Pomalidomide-PEG1-C2-N3 is an E3 ligase ligand-linker conjugate that combines a Pomalidomide-based cereblon ligand with a one-unit PEG linker, facilitating the development of PROTACs. This compound is particularly effective in creating selective CDK6 degrader molecules, such as CP-10, which induces CDK6 degradation with a DC50 of 2.1 nM. Additionally, Pomalidomide-PEG1-C2-N3 features an azide functionality that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, making it a versatile tool for click chemistry applications in chemical biology.
Chemical Information
| Catalog Num | A79945 |
|---|---|
| M. Wt | 386.36 |
| Formula | C17H18N6O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2271036-44-1 |
| Synonyms | Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCN=[N+]=[N-])=O |
Biological Activity
| Description | Pomalidomide-PEG1-C2-N3 is an E3 ligase ligand-linker conjugate that combines a Pomalidomide-based cereblon ligand with a one-unit PEG linker, facilitating the development of PROTACs. This compound is particularly effective in creating selective CDK6 degrader molecules, such as CP-10, which induces CDK6 degradation with a DC50 of 2.1 nM. Additionally, Pomalidomide-PEG1-C2-N3 features an azide functionality that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, making it a versatile tool for click chemistry applications in chemical biology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
