Product Data Sheet
Pomalidomide-PEG3-azide
Catalog No. A79948
Pomalidomide-PEG3-azide is an E3 ligase ligand-linker conjugate that combines the cereblon ligand derived from Pomalidomide with a three-unit polyethylene glycol (PEG) linker, essential for PROTAC (Proteolysis Targeting Chimeras) technology. This compound serves as a versatile click chemistry reagent, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. Its unique properties make it valuable for targeted protein degradation research and related applications in chemical biology.
Chemical Information
| Catalog Num | A79948 |
|---|---|
| M. Wt | 488.45 |
| Formula | C21H24N6O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2267306-15-8 |
| Synonyms | |
| SMILES | O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCN=[N+]=[N-] |
Biological Activity
| Description | Pomalidomide-PEG3-azide is an E3 ligase ligand-linker conjugate that combines the cereblon ligand derived from Pomalidomide with a three-unit polyethylene glycol (PEG) linker, essential for PROTAC (Proteolysis Targeting Chimeras) technology. This compound serves as a versatile click chemistry reagent, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. Its unique properties make it valuable for targeted protein degradation research and related applications in chemical biology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
