Product Data Sheet
Pomalidomide-PEG4-azide
Catalog No. A79949
Pomalidomide-PEG4-azide is an E3 ligase ligand-linker conjugate that features the Pomalidomide-based cereblon ligand, combined with a PEG4 linker for use in PROTAC technology. This compound serves as a versatile click chemistry reagent, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynyl-containing molecules, as well as enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It is primarily utilized in the development of targeted protein degradation strategies and other bioconjugation applications.
Chemical Information
| Catalog Num | A79949 |
|---|---|
| M. Wt | 518.52 |
| Formula | C23H30N6O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2271036-47-4 |
| Synonyms | |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOCCN=[N+]=[N-])=O |
Biological Activity
| Description | Pomalidomide-PEG4-azide is an E3 ligase ligand-linker conjugate that features the Pomalidomide-based cereblon ligand, combined with a PEG4 linker for use in PROTAC technology. This compound serves as a versatile click chemistry reagent, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynyl-containing molecules, as well as enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It is primarily utilized in the development of targeted protein degradation strategies and other bioconjugation applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
