Product Data Sheet
Pomalidomide-PEG2-COOH
Catalog No. A79956
Pomalidomide-PEG2-COOH is an E3 ligase ligand-linker conjugate that incorporates the Pomalidomide moiety known for its interaction with the cereblon protein and a two-unit polyethylene glycol (PEG) linker. This compound is designed for applications in PROTAC (proteolysis-targeting chimera) technology, enabling targeted protein degradation through the recruitment of E3 ubiquitin ligases. Its use facilitates the investigation of protein regulation and the modulation of cellular processes, making it a valuable tool for chemical biology research.
Chemical Information
| Catalog Num | A79956 |
|---|---|
| M. Wt | 433.41 |
| Formula | C20H23N3O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2140807-17-4 |
| Synonyms | Pomalidomide 4'-PEG2-acid |
| SMILES | O=C(O)CCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O |
Biological Activity
| Description | Pomalidomide-PEG2-COOH is an E3 ligase ligand-linker conjugate that incorporates the Pomalidomide moiety known for its interaction with the cereblon protein and a two-unit polyethylene glycol (PEG) linker. This compound is designed for applications in PROTAC (proteolysis-targeting chimera) technology, enabling targeted protein degradation through the recruitment of E3 ubiquitin ligases. Its use facilitates the investigation of protein regulation and the modulation of cellular processes, making it a valuable tool for chemical biology research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
