Product Data Sheet
Lenalidomide-propargyl-C2-NH2 hydrochloride
Catalog No. A79973
Lenalidomide-propargyl-C2-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that features a cereblon (CRBN) ligand, enabling targeted ubiquitination via the E3 ubiquitin ligase pathway. This compound serves as a critical component in the design of the PROTAC MD-224, facilitating targeted protein degradation. Additionally, Lenalidomide-propargyl-C2-NH2 hydrochloride functions as a click chemistry reagent, characterized by its alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties make it valuable for research applications focused on protein modulation and degradation.
Chemical Information
| Catalog Num | A79973 |
|---|---|
| M. Wt | 361.82 |
| Formula | C18H20ClN3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2489242-23-9 |
| Synonyms | |
| SMILES | O=C(C(N(CC1=C2C=CC=C1C#CCCCN)C2=O)CC3)NC3=O.Cl |
Biological Activity
| Description | Lenalidomide-propargyl-C2-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that features a cereblon (CRBN) ligand, enabling targeted ubiquitination via the E3 ubiquitin ligase pathway. This compound serves as a critical component in the design of the PROTAC MD-224, facilitating targeted protein degradation. Additionally, Lenalidomide-propargyl-C2-NH2 hydrochloride functions as a click chemistry reagent, characterized by its alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties make it valuable for research applications focused on protein modulation and degradation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
