Product Data Sheet
Lenalidomide-acetylene-C5-COOH
Catalog No. A79981
Lenalidomide-acetylene-C5-COOH serves as a ligand-linker conjugate targeting the E3 ligase Cereblon (CRBN). This compound facilitates the recruitment of CRBN and can be utilized to synthesize proteolysis-targeting chimeras (PROTACs) by conjugating to protein ligands through a linker. As a click chemistry reagent featuring an alkyne group, Lenalidomide-acetylene-C5-COOH is designed for copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling the efficient coupling with azide-containing molecules. This product is applicable in studies related to targeted protein degradation and novel therapeutic approaches in cancer research.
Chemical Information
| Catalog Num | A79981 |
|---|---|
| M. Wt | 382.41 |
| Formula | C21H22N2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2429878-72-6 |
| Synonyms | Cereblon ligand-linker Conjugate |
| SMILES | O=C1N(C2C(NC(CC2)=O)=O)CC3=C1C=CC=C3C#CCCCCCC(O)=O |
Biological Activity
| Description | Lenalidomide-acetylene-C5-COOH serves as a ligand-linker conjugate targeting the E3 ligase Cereblon (CRBN). This compound facilitates the recruitment of CRBN and can be utilized to synthesize proteolysis-targeting chimeras (PROTACs) by conjugating to protein ligands through a linker. As a click chemistry reagent featuring an alkyne group, Lenalidomide-acetylene-C5-COOH is designed for copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling the efficient coupling with azide-containing molecules. This product is applicable in studies related to targeted protein degradation and novel therapeutic approaches in cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
