Product Data Sheet
Thalidomide-O-C3-azide
Catalog No. A80009
Thalidomide-O-C3-azide is a modified form of the cereblon (CRBN) inhibitor, Thalidomide, featuring an azide group that enables efficient insertion into click chemistry reactions. This compound undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, making it a valuable tool for the synthesis of E3 ubiquitin ligase ligand-linker conjugates. Thalidomide-O-C3-azide is primarily utilized in the development of PROTACs, facilitating targeted protein degradation studies and advancing research in cellular signaling and therapeutic applications.
Chemical Information
| Catalog Num | A80009 |
|---|---|
| M. Wt | 357.32 |
| Formula | C16H15N5O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2758432-00-5 |
| Synonyms | |
| SMILES | [N-]=[N+]=NCCCOC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O |
Biological Activity
| Description | Thalidomide-O-C3-azide is a modified form of the cereblon (CRBN) inhibitor, Thalidomide, featuring an azide group that enables efficient insertion into click chemistry reactions. This compound undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, making it a valuable tool for the synthesis of E3 ubiquitin ligase ligand-linker conjugates. Thalidomide-O-C3-azide is primarily utilized in the development of PROTACs, facilitating targeted protein degradation studies and advancing research in cellular signaling and therapeutic applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
