Product Data Sheet
Pomalidomide-PEG6-NH2 hydrochloride
Catalog No. A80018
Pomalidomide-PEG6-NH2 hydrochloride is a conjugate designed for E3 ligase-mediated ubiquitination, combining the cereblon ligand derived from Pomalidomide with a six-unit polyethylene glycol (PEG) linker. This compound facilitates the development of PROTAC (proteolysis-targeting chimeras) by enabling targeted protein degradation through the recruitment of E3 ligases. Its unique structure supports applications in drug discovery and targeted therapy research, particularly for modulating protein levels within cellular systems.
Chemical Information
| Catalog Num | A80018 |
|---|---|
| M. Wt | 574.02 |
| Formula | C25H36ClN3O10 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2341841-01-6 |
| Synonyms | |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCCOCCN)=O.[H]Cl |
Biological Activity
| Description | Pomalidomide-PEG6-NH2 hydrochloride is a conjugate designed for E3 ligase-mediated ubiquitination, combining the cereblon ligand derived from Pomalidomide with a six-unit polyethylene glycol (PEG) linker. This compound facilitates the development of PROTAC (proteolysis-targeting chimeras) by enabling targeted protein degradation through the recruitment of E3 ligases. Its unique structure supports applications in drug discovery and targeted therapy research, particularly for modulating protein levels within cellular systems. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
