Product Data Sheet
(S,R,S)-AHPC-O-Ph-PEG1-NH2
Catalog No. A80022
(S,R,S)-AHPC-O-Ph-PEG1-NH2 is an E3 ligase ligand-linker conjugate, designed to incorporate a VHL ligand that targets the E3 ubiquitin ligase. This compound serves as a critical component in the development of PROTAC molecules, specifically utilized in the PROTAC EED degrader-1, which targets the EED protein with a pKD of 9.02. Its application is relevant in studies of targeted protein degradation and cellular signaling pathways, making it valuable for research in cancer and other diseases influenced by protein homeostasis.
Chemical Information
| Catalog Num | A80022 |
|---|---|
| M. Wt | 623.76 |
| Formula | C32H41N5O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2361117-24-8 |
| Synonyms | VH032-O-Ph-PEG1-NH2 |
| SMILES | NCCOC1=CC=C(C=C1)OCC(N[C@H](C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C=C3)C4=C(N=CS4)C)=O)=O)C(C)(C)C)=O |
Biological Activity
| Description | (S,R,S)-AHPC-O-Ph-PEG1-NH2 is an E3 ligase ligand-linker conjugate, designed to incorporate a VHL ligand that targets the E3 ubiquitin ligase. This compound serves as a critical component in the development of PROTAC molecules, specifically utilized in the PROTAC EED degrader-1, which targets the EED protein with a pKD of 9.02. Its application is relevant in studies of targeted protein degradation and cellular signaling pathways, making it valuable for research in cancer and other diseases influenced by protein homeostasis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
