Product Data Sheet
Thalidomide-O-amido-PEG4-C2-NH2
Catalog No. A80073
Thalidomide-O-amido-PEG4-C2-NH2 is an engineered E3 ligase ligand-linker conjugate that features a thalidomide-derived cereblon ligand combined with a PEG4 linker. This compound is designed to facilitate targeted protein degradation via PROTAC (Proteolysis Targeting Chimera) technology, enabling the selective modulation of protein levels in cellular systems. Its applications include studying protein degradation pathways and developing therapeutic strategies that leverage the ubiquitin-proteasome system for enhanced drug efficacy.
Chemical Information
| Catalog Num | A80073 |
|---|---|
| M. Wt | 550.56 |
| Formula | C25H34N4O10 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1957236-22-4 |
| Synonyms | |
| SMILES | O=C(NCCOCCOCCOCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O |
Biological Activity
| Description | Thalidomide-O-amido-PEG4-C2-NH2 is an engineered E3 ligase ligand-linker conjugate that features a thalidomide-derived cereblon ligand combined with a PEG4 linker. This compound is designed to facilitate targeted protein degradation via PROTAC (Proteolysis Targeting Chimera) technology, enabling the selective modulation of protein levels in cellular systems. Its applications include studying protein degradation pathways and developing therapeutic strategies that leverage the ubiquitin-proteasome system for enhanced drug efficacy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
