Product Data Sheet
E3 Ligase Ligand-linker Conjugate 133
Catalog No. A80106
E3 Ligase Ligand-linker Conjugate 133 is a synthesized conjugate comprising an E3 ligase ligand and a linker, functioning as a crucial intermediate in the development of the PROTAC molecule pan-KRAS degrader 4. This compound facilitates targeted protein degradation by leveraging the ubiquitin-proteasome system, making it essential for studies related to targeted cancer therapeutics and protein modulation. Its application in PROTAC research highlights its potential in advancing therapeutic strategies against malignancies associated with KRAS mutations.
Chemical Information
| Catalog Num | A80106 |
|---|---|
| M. Wt | 539.68 |
| Formula | C30H42FN5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3052750-99-6 |
| Synonyms | |
| SMILES | O=C(N(CC1=C2F)C3CCC(NC3=O)=O)C1=CC=C2N(CC4)CCC4CN(CC5)CCC5CC6CCNCC6 |
Biological Activity
| Description | E3 Ligase Ligand-linker Conjugate 133 is a synthesized conjugate comprising an E3 ligase ligand and a linker, functioning as a crucial intermediate in the development of the PROTAC molecule pan-KRAS degrader 4. This compound facilitates targeted protein degradation by leveraging the ubiquitin-proteasome system, making it essential for studies related to targeted cancer therapeutics and protein modulation. Its application in PROTAC research highlights its potential in advancing therapeutic strategies against malignancies associated with KRAS mutations. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
