Product Data Sheet
Pomalidomide-PEG4-C2-NH2 TFA
Catalog No. A80142
Pomalidomide-PEG4-C2-NH2 TFA is an E3 ligase ligand-linker conjugate that combines the Pomalidomide-derived cereblon ligand with a four-unit polyethylene glycol (PEG) linker. This compound serves as a critical component in PROTAC (proteolysis-targeting chimeras) technology, facilitating targeted protein degradation. Its design enables efficient recruitment of E3 ubiquitin ligases, enhancing the regulation of protein levels in research applications focused on protein homeostasis and therapeutic development.
Chemical Information
| Catalog Num | A80142 |
|---|---|
| M. Wt | 606.55 |
| Formula | C25H33F3N4O10 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2710221-73-9 |
| Synonyms | Cereblon Ligand-Linker Conjugates 8 TFA; E3 Ligase Ligand-Linker Conjugates 22 TFA |
| SMILES | O=C(C(F)(F)F)O.O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCOCCOCCN)=CC=C3)=O)=O |
Biological Activity
| Description | Pomalidomide-PEG4-C2-NH2 TFA is an E3 ligase ligand-linker conjugate that combines the Pomalidomide-derived cereblon ligand with a four-unit polyethylene glycol (PEG) linker. This compound serves as a critical component in PROTAC (proteolysis-targeting chimeras) technology, facilitating targeted protein degradation. Its design enables efficient recruitment of E3 ubiquitin ligases, enhancing the regulation of protein levels in research applications focused on protein homeostasis and therapeutic development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
