Product Data Sheet
E3 Ligase Ligand-linker Conjugate 183
Catalog No. A80188
E3 Ligase Ligand-Linker Conjugate 183 is designed to target E3 ligases, facilitating the selective degradation of protein substrates through the ubiquitin-proteasome system. This conjugate features the LC3B ligand 2, which enhances autophagic degradation, and an optimized linker for effective delivery. Its applications include studies on protein turnover, cellular homeostasis, and targeted protein degradation, particularly in the context of PCSK9 regulation.
Chemical Information
| Catalog Num | A80188 |
|---|---|
| M. Wt | 760.05 |
| Formula | C23H23Br3INO5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3081572-35-9 |
| Synonyms | |
| SMILES | O=C1N(CCOCCOCCOCCBr)C2=C(C=C(I)C=C2)/C1=C\C3=CC(Br)=C(O)C(Br)=C3 |
Biological Activity
| Description | E3 Ligase Ligand-Linker Conjugate 183 is designed to target E3 ligases, facilitating the selective degradation of protein substrates through the ubiquitin-proteasome system. This conjugate features the LC3B ligand 2, which enhances autophagic degradation, and an optimized linker for effective delivery. Its applications include studies on protein turnover, cellular homeostasis, and targeted protein degradation, particularly in the context of PCSK9 regulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
