Product Data Sheet
Thalidomide-S-C6-acid
Catalog No. A80210
Thalidomide-S-C6-acid is a synthetic E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a C6 linker. This compound facilitates the development of PROTACs, specifically designed for targeted protein degradation applications, including the synthesis of the PROTAC Cas9 Degrader-1. Its ability to engage with E3 ligases makes it a valuable tool in biochemistry and molecular biology research focused on therapeutic interventions through targeted protein modulation.
Chemical Information
| Catalog Num | A80210 |
|---|---|
| M. Wt | 404.48 |
| Formula | C20H24N2O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2378582-45-5 |
| Synonyms | |
| SMILES | O=C(O)CCCCCCSC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O |
Biological Activity
| Description | Thalidomide-S-C6-acid is a synthetic E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a C6 linker. This compound facilitates the development of PROTACs, specifically designed for targeted protein degradation applications, including the synthesis of the PROTAC Cas9 Degrader-1. Its ability to engage with E3 ligases makes it a valuable tool in biochemistry and molecular biology research focused on therapeutic interventions through targeted protein modulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
