Product Data Sheet
E3 Ligase Ligand-linker Conjugate 115
Catalog No. A80222
E3 Ligase Ligand-linker Conjugate 115 is a potent E3 ubiquitin ligase ligand combined with a linker, designed for the development of targeted protein degradation strategies. This compound serves as a crucial component in synthesizing PROTAC SMARCA2/4-degrader-27, enabling researchers to investigate the modulation of specific protein levels through ubiquitin-proteasome pathway engagement. Its application in chemical biology provides a valuable tool for studying protein function and regulation in various cellular contexts.
Chemical Information
| Catalog Num | A80222 |
|---|---|
| M. Wt | 708.84 |
| Formula | C37H45FN4O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2375564-59-1 |
| Synonyms | |
| SMILES | O=C(N[C@H](C(N1[C@H](C(NCC2=C(OCCC3=CC=C(C=C3)C4OCCO4)C=C(C=C2)C5=C(N=CS5)C)=O)C[C@@H](O)C1)=O)C(C)(C)C)C6(F)CC6 |
Biological Activity
| Description | E3 Ligase Ligand-linker Conjugate 115 is a potent E3 ubiquitin ligase ligand combined with a linker, designed for the development of targeted protein degradation strategies. This compound serves as a crucial component in synthesizing PROTAC SMARCA2/4-degrader-27, enabling researchers to investigate the modulation of specific protein levels through ubiquitin-proteasome pathway engagement. Its application in chemical biology provides a valuable tool for studying protein function and regulation in various cellular contexts. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
