Product Data Sheet
CRBN ligand-8-O-C6-NH2
Catalog No. A80228
CRBN ligand-8-O-C6-NH2 is an E3 ligase ligand-linker conjugate that targets the cereblon (CRBN) E3 ubiquitin ligase, facilitating targeted protein degradation. This compound serves as a critical component in the synthesis of PROTAC ERα Degrader-11, thus aiding in the study of estrogen receptor-alpha (ERα) modulation and its associated cellular pathways. Researchers can utilize CRBN ligand-8-O-C6-NH2 for advancing the development of targeted therapeutic strategies in cancer and other diseases influenced by ERα signaling.
Chemical Information
| Catalog Num | A80228 |
|---|---|
| M. Wt | 423.46 |
| Formula | C23H25N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2407829-84-7 |
| Synonyms | |
| SMILES | O=C1C(CCC(N1)=O)N2C(C3=CC(OCCCCCCN)=CC4=CC=CC(C2=O)=C43)=O |
Biological Activity
| Description | CRBN ligand-8-O-C6-NH2 is an E3 ligase ligand-linker conjugate that targets the cereblon (CRBN) E3 ubiquitin ligase, facilitating targeted protein degradation. This compound serves as a critical component in the synthesis of PROTAC ERα Degrader-11, thus aiding in the study of estrogen receptor-alpha (ERα) modulation and its associated cellular pathways. Researchers can utilize CRBN ligand-8-O-C6-NH2 for advancing the development of targeted therapeutic strategies in cancer and other diseases influenced by ERα signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
