Product Data Sheet
E3 Ligase Ligand-linker Conjugate 91
Catalog No. A80275
E3 Ligase Ligand-Linker Conjugate 91 is a conjugate composed of an E3 ligase ligand and a linker, featuring (S,R,S)-AHPC, a von Hippel-Lindau (VHL) ligand that effectively recruits VHL proteins. This compound serves as a crucial intermediate in the development of complete PROTAC (proteolysis-targeting chimera) molecules, enabling targeted protein degradation. Its application is significant in the exploration of innovative therapeutic strategies within chemical biology and drug discovery.
Chemical Information
| Catalog Num | A80275 |
|---|---|
| M. Wt | 700.89 |
| Formula | C35H52N6O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2229713-40-8 |
| Synonyms | |
| SMILES | O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(COCCN2CCN(CC2)C(OC(C)(C)C)=O)=O)=O)NCC(C=C3)=CC=C3C(SC=N4)=C4C |
Biological Activity
| Description | E3 Ligase Ligand-Linker Conjugate 91 is a conjugate composed of an E3 ligase ligand and a linker, featuring (S,R,S)-AHPC, a von Hippel-Lindau (VHL) ligand that effectively recruits VHL proteins. This compound serves as a crucial intermediate in the development of complete PROTAC (proteolysis-targeting chimera) molecules, enabling targeted protein degradation. Its application is significant in the exploration of innovative therapeutic strategies within chemical biology and drug discovery. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
