Product Data Sheet
(S,R,S)-AHPC-PEG3-NH2 dihydrochloride
Catalog No. A80286
(S,R,S)-AHPC-PEG3-NH2 dihydrochloride is an E3 ligase ligand-linker conjugate designed for use in PROTAC technology. This compound features the (S,R,S)-AHPC ligand, which selectively targets von Hippel-Lindau (VHL) E3 ligases, and is equipped with a three-unit polyethylene glycol (PEG) linker to enhance solubility and target specificity. It is suitable for facilitating the degradation of target proteins in research applications related to protein homeostasis and therapeutic development.
Chemical Information
| Catalog Num | A80286 |
|---|---|
| M. Wt | 692.69 |
| Formula | C30H47Cl2N5O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2376990-24-6 |
| Synonyms | VH032-PEG3-NH2 dihydrochloride; VHL Ligand-Linker Conjugates 1 dihydrochloride; E3 ligase Ligand-Linker Conjugates 5 dihydrochloride |
| SMILES | [H]Cl.O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(COCCOCCOCCN)=O)=O)C[C@H](O)C3.[H]Cl |
Biological Activity
| Description | (S,R,S)-AHPC-PEG3-NH2 dihydrochloride is an E3 ligase ligand-linker conjugate designed for use in PROTAC technology. This compound features the (S,R,S)-AHPC ligand, which selectively targets von Hippel-Lindau (VHL) E3 ligases, and is equipped with a three-unit polyethylene glycol (PEG) linker to enhance solubility and target specificity. It is suitable for facilitating the degradation of target proteins in research applications related to protein homeostasis and therapeutic development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
