Product Data Sheet
Thalidomide-O-CONH-alkyne
Catalog No. A80330
Thalidomide-O-CONH-alkyne is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN) ligand and a spacer moiety. This compound is designed for the synthesis of PROTACs (proteolysis-targeting chimeras), which facilitate targeted degradation of proteins by harnessing the ubiquitin-proteasome system. Its utility in drug discovery and therapeutic development makes it a valuable tool for researchers investigating targeted protein modulation.
Chemical Information
| Catalog Num | A80330 |
|---|---|
| M. Wt | 369.33 |
| Formula | C18H15N3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2738967-56-9 |
| Synonyms | |
| SMILES | O=C1NC(=O)C(N2C(=O)C=3C=CC=C(OCC(=O)NCC#C)C3C2=O)CC1 |
Biological Activity
| Description | Thalidomide-O-CONH-alkyne is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN) ligand and a spacer moiety. This compound is designed for the synthesis of PROTACs (proteolysis-targeting chimeras), which facilitate targeted degradation of proteins by harnessing the ubiquitin-proteasome system. Its utility in drug discovery and therapeutic development makes it a valuable tool for researchers investigating targeted protein modulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
