Product Data Sheet
(R,S,S)-VH032-PEG5-N3
Catalog No. A80368
(R,S,S)-VH032-PEG5-N3 is an E3 ligase ligand-linker conjugate that combines a VHL ligand, derived from VH032, with a five-unit PEG linker. This compound serves as a versatile click chemistry reagent featuring an azide group, which facilitates copper-catalyzed azido-alkyne cycloaddition (CuAAc) when interacting with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted azide-alkyne cycloaddition (SPAAC) with compounds containing DBCO or BCN groups, making it valuable for targeted protein degradation studies and related applications in chemical biology.
Chemical Information
| Catalog Num | A80368 |
|---|---|
| M. Wt | 733.88 |
| Formula | C34H51N7O9S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2766352-74-1 |
| Synonyms | |
| SMILES | C([C@@H](NC(COCCOCCOCCOCCOCCN=[N+]=[N-])=O)[C@](C)(C)C)(=O)N1[C@@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](O)C1 |
Biological Activity
| Description | (R,S,S)-VH032-PEG5-N3 is an E3 ligase ligand-linker conjugate that combines a VHL ligand, derived from VH032, with a five-unit PEG linker. This compound serves as a versatile click chemistry reagent featuring an azide group, which facilitates copper-catalyzed azido-alkyne cycloaddition (CuAAc) when interacting with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted azide-alkyne cycloaddition (SPAAC) with compounds containing DBCO or BCN groups, making it valuable for targeted protein degradation studies and related applications in chemical biology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
