Product Data Sheet
Thalidomide-O-PEG5-tosyl
Catalog No. A80374
Thalidomide-O-PEG5-tosyl is an E3 ligase ligand-linker conjugate that utilizes a Thalidomide-derived cereblon ligand in combination with a 4-unit polyethylene glycol (PEG) linker. This compound is designed for use in PROTAC technology, facilitating the recruitment of E3 ligases to target proteins for ubiquitination and subsequent degradation. Thalidomide-O-PEG5-tosyl demonstrates reactivity with nucleophiles, including amine and hydroxy-containing molecules, making it a valuable tool for researchers studying targeted protein degradation and related pathways.
Chemical Information
| Catalog Num | A80374 |
|---|---|
| M. Wt | 648.68 |
| Formula | C30H36N2O12S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2414905-34-1 |
| Synonyms | |
| SMILES | O=C1NC(C(CC1)N2C(C3=C(C2=O)C(OCCOCCOCCOCCOCCOS(=O)(C4=CC=C(C)C=C4)=O)=CC=C3)=O)=O |
Biological Activity
| Description | Thalidomide-O-PEG5-tosyl is an E3 ligase ligand-linker conjugate that utilizes a Thalidomide-derived cereblon ligand in combination with a 4-unit polyethylene glycol (PEG) linker. This compound is designed for use in PROTAC technology, facilitating the recruitment of E3 ligases to target proteins for ubiquitination and subsequent degradation. Thalidomide-O-PEG5-tosyl demonstrates reactivity with nucleophiles, including amine and hydroxy-containing molecules, making it a valuable tool for researchers studying targeted protein degradation and related pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
