Product Data Sheet
Thalidomide-3,8-diazabicyclo[3.2.1]octane-Boc
Catalog No. A80377
Thalidomide-3,8-diazabicyclo[3.2.1]octane-Boc is an E3 ligase ligand-linker conjugate that incorporates a CRBN-based ligand and a linker structure, facilitating the synthesis of PROTACs. This compound is instrumental in targeted protein degradation research, enabling precise modulation of protein levels within cells. Its unique design allows for effective recruitment of E3 ligases in various biological systems, making it a valuable tool for exploring protein homeostasis and therapeutic applications in diseases.
Chemical Information
| Catalog Num | A80377 |
|---|---|
| M. Wt | 468.50 |
| Formula | C24H28N4O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2740655-32-5 |
| Synonyms | |
| SMILES | O=C(N1C2CN(CC1CC2)C3=CC=C4C(N(C5C(NC(CC5)=O)=O)C(C4=C3)=O)=O)OC(C)(C)C |
Biological Activity
| Description | Thalidomide-3,8-diazabicyclo[3.2.1]octane-Boc is an E3 ligase ligand-linker conjugate that incorporates a CRBN-based ligand and a linker structure, facilitating the synthesis of PROTACs. This compound is instrumental in targeted protein degradation research, enabling precise modulation of protein levels within cells. Its unique design allows for effective recruitment of E3 ligases in various biological systems, making it a valuable tool for exploring protein homeostasis and therapeutic applications in diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
