Product Data Sheet
Thalidomide-piperazine-C-azetidine TFA
Catalog No. A80383
Thalidomide-piperazine-C-azetidine TFA is an E3 ligase ligand-linker conjugate that features a CRBN-based ligand integrated with a linker moiety. This compound is designed for the synthesis of PROteolysis TArgeting Chimeras (PROTACs), facilitating targeted protein degradation pathways. Its application in research primarily includes the exploration of E3 ligase-mediated ubiquitination processes and the development of targeted therapies in drug discovery.
Chemical Information
| Catalog Num | A80383 |
|---|---|
| M. Wt | 525.48 |
| Formula | C23H26F3N5O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2791286-89-8 |
| Synonyms | |
| SMILES | O=C1NC(C(CC1)N2C(C3=CC=C(N4CCN(CC5CNC5)CC4)C=C3C2=O)=O)=O.O=C(C(F)(F)F)O |
Biological Activity
| Description | Thalidomide-piperazine-C-azetidine TFA is an E3 ligase ligand-linker conjugate that features a CRBN-based ligand integrated with a linker moiety. This compound is designed for the synthesis of PROteolysis TArgeting Chimeras (PROTACs), facilitating targeted protein degradation pathways. Its application in research primarily includes the exploration of E3 ligase-mediated ubiquitination processes and the development of targeted therapies in drug discovery. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
