Product Data Sheet
Pomalidomide-C3-alkyne
Catalog No. A80406
Pomalidomide-C3-alkyne is an E3 ligase ligand-linker conjugate that incorporates a ceramide-based ligand (CRBN) and a linker moiety, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables selective protein degradation by harnessing the ubiquitin-proteasome system, making it valuable for studies in targeted therapy and drug development. Its utility in research applications includes investigating protein-protein interactions and exploring new therapeutic strategies for various diseases.
Chemical Information
| Catalog Num | A80406 |
|---|---|
| M. Wt | 339.35 |
| Formula | C18H17N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2154356-75-7 |
| Synonyms | |
| SMILES | O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCC#C)C3C2=O)CC1 |
Biological Activity
| Description | Pomalidomide-C3-alkyne is an E3 ligase ligand-linker conjugate that incorporates a ceramide-based ligand (CRBN) and a linker moiety, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables selective protein degradation by harnessing the ubiquitin-proteasome system, making it valuable for studies in targeted therapy and drug development. Its utility in research applications includes investigating protein-protein interactions and exploring new therapeutic strategies for various diseases. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
