Product Data Sheet
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3
Catalog No. A80419
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 is an E3 ligase ligand-linker conjugate designed for applications in PROTAC (proteolysis targeting chimera) technology. This compound features the (4R,5S)-Nutlin carboxylic acid, a potent MDM2 inhibitor, facilitating targeted degradation of proteins by linking to an E3 ligase. It is essential for developing PROTACs aimed at directing specific therapeutic pathways for proteins such as EZH2.
Chemical Information
| Catalog Num | A80419 |
|---|---|
| M. Wt | 795.71 |
| Formula | C38H44Cl2N8O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3035510-04-1 |
| Synonyms | |
| SMILES | O=C(N1CC(N(CC1)CC(NCCOCCOCCN=[N+]=[N-])=O)=O)N2[C@@H](C3=CC=C(C=C3)Cl)[C@@H](C4=CC=C(C=C4)Cl)N=C2C5=C(C=C(C=C5)OC)OC(C)C |
Biological Activity
| Description | (4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 is an E3 ligase ligand-linker conjugate designed for applications in PROTAC (proteolysis targeting chimera) technology. This compound features the (4R,5S)-Nutlin carboxylic acid, a potent MDM2 inhibitor, facilitating targeted degradation of proteins by linking to an E3 ligase. It is essential for developing PROTACs aimed at directing specific therapeutic pathways for proteins such as EZH2. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
