Product Data Sheet
Thalidomide-NH-C10-Boc
Catalog No. A80432
Thalidomide-NH-C10-Boc is a conjugate designed as an E3 ubiquitinase ligand-linker, facilitating the recruitment of the Cereblon ubiquitinase. This compound enables the synthesis of PROTAC molecules that induce targeted protein degradation, through its versatile PTOTAC linker. It has applications in developing therapeutics by coupling with specific ligands, such as EP300/CBP ligand 2, to create PROTACs that promote proteolytic activity against designated targets.
Chemical Information
| Catalog Num | A80432 |
|---|---|
| M. Wt | 513.63 |
| Formula | C28H39N3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2428400-25-1 |
| Synonyms | |
| SMILES | O=C(N1C2CCC(NC2=O)=O)C3=CC=CC(NCCCCCCCCCCC(OC(C)(C)C)=O)=C3C1=O |
Biological Activity
| Description | Thalidomide-NH-C10-Boc is a conjugate designed as an E3 ubiquitinase ligand-linker, facilitating the recruitment of the Cereblon ubiquitinase. This compound enables the synthesis of PROTAC molecules that induce targeted protein degradation, through its versatile PTOTAC linker. It has applications in developing therapeutics by coupling with specific ligands, such as EP300/CBP ligand 2, to create PROTACs that promote proteolytic activity against designated targets. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
