Product Data Sheet
VH 101, thiol
Catalog No. A80524
VH 101, thiol serves as a selective VHL ligand, primarily utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enables the targeted degradation of specific proteins by harnessing the ubiquitin-proteasome system, making it instrumental in drug discovery and therapeutic research. Its robust binding affinity and specificity towards VHL provide an effective tool for studies aimed at elucidating protein regulation mechanisms and developing novel treatments for various diseases.
Chemical Information
| Catalog Num | A80524 |
|---|---|
| M. Wt | 534.67 |
| Formula | C25H31FN4O4S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2358775-81-0 |
| Synonyms | |
| SMILES | O=C(C1(CC1)F)N[C@@H](C(C)(S)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(N=CS4)C)C=C3)=O)=O |
Biological Activity
| Description | VH 101, thiol serves as a selective VHL ligand, primarily utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enables the targeted degradation of specific proteins by harnessing the ubiquitin-proteasome system, making it instrumental in drug discovery and therapeutic research. Its robust binding affinity and specificity towards VHL provide an effective tool for studies aimed at elucidating protein regulation mechanisms and developing novel treatments for various diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
