Product Data Sheet
E3 ligase Ligand 18
Catalog No. A80543
E3 Ligase Ligand 18 is a selective ligand for E3 ubiquitin ligases, facilitating the targeted degradation of proteins through the ubiquitin-proteasome system. When conjugated to a target protein via a linker, it forms a PROTAC (proteolysis-targeting chimera), which effectively induces ubiquitination and subsequent degradation of cancer-associated proteins. This reagent is valuable in research focused on protein degradation pathways and may contribute to therapeutic strategies for cancer treatment.
Chemical Information
| Catalog Num | A80543 |
|---|---|
| M. Wt | 436.87 |
| Formula | C17H17ClN6O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2241669-88-3 |
| Synonyms | |
| SMILES | CC(N[C@H](C(O)=O)CSC1=NC(C(N=C(N)N2)=O)=C2N1CC3=CC=C(Cl)C=C3)=O |
Biological Activity
| Description | E3 Ligase Ligand 18 is a selective ligand for E3 ubiquitin ligases, facilitating the targeted degradation of proteins through the ubiquitin-proteasome system. When conjugated to a target protein via a linker, it forms a PROTAC (proteolysis-targeting chimera), which effectively induces ubiquitination and subsequent degradation of cancer-associated proteins. This reagent is valuable in research focused on protein degradation pathways and may contribute to therapeutic strategies for cancer treatment. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
