Product Data Sheet
VH032-NH-CO-CH2-NHBoc
Catalog No. A80637
VH032-NH-CO-CH2-NHBoc is a Boc-modified ligand that targets the von Hippel-Lindau (VHL) protein, functioning as a crucial component for developing Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the recruitment of VHL to specific target proteins, enabling targeted degradation of these proteins through the ubiquitin-proteasome pathway. Under acidic conditions, VH032-NH-CO-CH2-NHBoc removes the Boc protection, allowing for the formation of PROTAC molecules that capitalize on VHL's E3 ligase activity. Its application is significant in studies focusing on targeted protein degradation and therapeutic development.
Chemical Information
| Catalog Num | A80637 |
|---|---|
| M. Wt | 587.73 |
| Formula | C29H41N5O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2010986-19-1 |
| Synonyms | |
| SMILES | O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CNC(OC(C)(C)C)=O)=O)=O)C[C@H](O)C3 |
Biological Activity
| Description | VH032-NH-CO-CH2-NHBoc is a Boc-modified ligand that targets the von Hippel-Lindau (VHL) protein, functioning as a crucial component for developing Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the recruitment of VHL to specific target proteins, enabling targeted degradation of these proteins through the ubiquitin-proteasome pathway. Under acidic conditions, VH032-NH-CO-CH2-NHBoc removes the Boc protection, allowing for the formation of PROTAC molecules that capitalize on VHL's E3 ligase activity. Its application is significant in studies focusing on targeted protein degradation and therapeutic development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
