Product Data Sheet
CRBN ligand-423
Catalog No. A80722
CRBN ligand-423 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that plays a critical role in targeted protein degradation. This compound facilitates the recruitment of CRBN to specific target proteins and can be combined with target protein ligands through a linker to create a PROTAC (proteolysis-targeting chimera). Its application in the development of PROTACs provides valuable insights into the modulation of protein levels for therapeutic purposes in various biological research areas.
Chemical Information
| Catalog Num | A80722 |
|---|---|
| M. Wt | 269.26 |
| Formula | C14H11N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2925089-32-1 |
| Synonyms | |
| SMILES | O=CC=1C=CN=C2C=CC(=CC21)N3C(=O)NC(=O)CC3 |
Biological Activity
| Description | CRBN ligand-423 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that plays a critical role in targeted protein degradation. This compound facilitates the recruitment of CRBN to specific target proteins and can be combined with target protein ligands through a linker to create a PROTAC (proteolysis-targeting chimera). Its application in the development of PROTACs provides valuable insights into the modulation of protein levels for therapeutic purposes in various biological research areas. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
