Product Data Sheet
CRBN ligand-728
Catalog No. A80724
CRBN ligand-728 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN proteins. This compound is pivotal in the development of proteolysis-targeting chimeras (PROTACs) by enabling the linkage of target protein ligands through a suitable linker. Its use in research focuses on exploring targeted protein degradation pathways, advancing the understanding of cellular regulation, and uncovering therapeutic strategies in various diseases.
Chemical Information
| Catalog Num | A80724 |
|---|---|
| M. Wt | 272.26 |
| Formula | C13H12N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2925082-68-2 |
| Synonyms | |
| SMILES | O=CC1=C2C=C(C=CC2=NN1C)N3C(=O)NC(=O)CC3 |
Biological Activity
| Description | CRBN ligand-728 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN proteins. This compound is pivotal in the development of proteolysis-targeting chimeras (PROTACs) by enabling the linkage of target protein ligands through a suitable linker. Its use in research focuses on exploring targeted protein degradation pathways, advancing the understanding of cellular regulation, and uncovering therapeutic strategies in various diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
