Product Data Sheet
CRBN ligand-619
Catalog No. A80789
CRBN ligand-619 is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment for protein degradation processes. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera) for effective modulation of protein levels. CRBN ligand-619 is valuable for research applications in protein homeostasis, targeted therapy development, and the investigation of ubiquitin-proteasome system dynamics.
Chemical Information
| Catalog Num | A80789 |
|---|---|
| M. Wt | 324.13 |
| Formula | C12H10BrN3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2229724-66-5 |
| Synonyms | |
| SMILES | O=C1NC(=O)C(N2C(=O)C3=CC=C(Br)N=C3C2)CC1 |
Biological Activity
| Description | CRBN ligand-619 is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment for protein degradation processes. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera) for effective modulation of protein levels. CRBN ligand-619 is valuable for research applications in protein homeostasis, targeted therapy development, and the investigation of ubiquitin-proteasome system dynamics. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
