Product Data Sheet
SJ6145
Catalog No. A81021
SJ6145 is a potent ligand for KLHDC2, exhibiting a dissociation constant (Kd) of 16.9 μM as determined by surface plasmon resonance (SPR) assays. This compound demonstrates an IC50 value of 42 μM in inhibiting KLHDC2's binding to a di-Gly degron peptide, highlighting its potential role in investigating KLHDC2-mediated cellular processes. SJ6145 can be utilized in research applications focused on protein degradation and regulatory mechanisms in cellular homeostasis.
Chemical Information
| Catalog Num | A81021 |
|---|---|
| M. Wt | 294.30 |
| Formula | C13H11FN2O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1010913-79-7 |
| Synonyms | |
| SMILES | O=C(CNC(CC1=CSC(C2=C(C=CC=C2)F)=N1)=O)O |
Biological Activity
| Description | SJ6145 is a potent ligand for KLHDC2, exhibiting a dissociation constant (Kd) of 16.9 μM as determined by surface plasmon resonance (SPR) assays. This compound demonstrates an IC50 value of 42 μM in inhibiting KLHDC2's binding to a di-Gly degron peptide, highlighting its potential role in investigating KLHDC2-mediated cellular processes. SJ6145 can be utilized in research applications focused on protein degradation and regulatory mechanisms in cellular homeostasis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
