Product Data Sheet
CRBN ligand-108
Catalog No. A81248
CRBN ligand-108 is an E3 ubiquitin ligase ligand that targets the cereblon (CRBN) component of the CRL4 E3 ligase complex. This compound facilitates the recruitment of target proteins for ubiquitination and subsequent degradation via the proteasome. CRBN ligand-108 is particularly valuable in the development of PROTACs (proteolysis-targeting chimeras) for targeted protein degradation research applications. Its utility extends to exploring therapeutic strategies in cancer and other diseases by modulating protein levels.
Chemical Information
| Catalog Num | A81248 |
|---|---|
| M. Wt | 293.12 |
| Formula | C12H9BrN2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3036607-80-1 |
| Synonyms | |
| SMILES | N#CC1=CC(C(CC2)C(NC2=O)=O)=CC=C1Br |
Biological Activity
| Description | CRBN ligand-108 is an E3 ubiquitin ligase ligand that targets the cereblon (CRBN) component of the CRL4 E3 ligase complex. This compound facilitates the recruitment of target proteins for ubiquitination and subsequent degradation via the proteasome. CRBN ligand-108 is particularly valuable in the development of PROTACs (proteolysis-targeting chimeras) for targeted protein degradation research applications. Its utility extends to exploring therapeutic strategies in cancer and other diseases by modulating protein levels. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
