Product Data Sheet
Propargyl-PEG1-acid
Catalog No. A81547
Propargyl-PEG1-acid is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the synthesis of BTK-CRBN PROTACs, specifically enhancing the degradation of Bruton’s Tyrosine Kinase (BTK), as well as other key proteins such as CSK, LYN, and LAT2, when utilized at concentrations of 10 μM. Featuring an alkyne functional group, Propargyl-PEG1-acid enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it an essential tool for researchers developing targeted protein degradation strategies.
Chemical Information
| Catalog Num | A81547 |
|---|---|
| M. Wt | 128.13 |
| Formula | C6H8O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 55683-37-9 |
| Synonyms | |
| SMILES | O=C(O)CCOCC#C |
Biological Activity
| Description | Propargyl-PEG1-acid is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the synthesis of BTK-CRBN PROTACs, specifically enhancing the degradation of Bruton’s Tyrosine Kinase (BTK), as well as other key proteins such as CSK, LYN, and LAT2, when utilized at concentrations of 10 μM. Featuring an alkyne functional group, Propargyl-PEG1-acid enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it an essential tool for researchers developing targeted protein degradation strategies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
