Product Data Sheet
N-Fmoc-8-aminooctanoic acid
Catalog No. A81807
N-Fmoc-8-aminooctanoic acid serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain that includes a terminal Fmoc-protected amine and a carboxylic acid group. The Fmoc group can be removed under basic conditions to yield a free amine amenable for further modifications. Additionally, the carboxylic acid can react with primary amines in the presence of coupling agents, such as EDC or HATU, to establish stable amide bonds, thus enhancing the structural diversity of PROTAC molecules for targeted protein degradation studies.
Chemical Information
| Catalog Num | A81807 |
|---|---|
| M. Wt | 381.46 |
| Formula | C23H27NO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 126631-93-4 |
| Synonyms | |
| SMILES | OC(CCCCCCCNC(OCC1C2=CC=CC=C2C3=C1C=CC=C3)=O)=O |
Biological Activity
| Description | N-Fmoc-8-aminooctanoic acid serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain that includes a terminal Fmoc-protected amine and a carboxylic acid group. The Fmoc group can be removed under basic conditions to yield a free amine amenable for further modifications. Additionally, the carboxylic acid can react with primary amines in the presence of coupling agents, such as EDC or HATU, to establish stable amide bonds, thus enhancing the structural diversity of PROTAC molecules for targeted protein degradation studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
