Product Data Sheet
3,9-Dimethyl-3,9-diazaspiro[5.5]undecane
Catalog No. A82165
3,9-Dimethyl-3,9-diazaspiro[5.5]undecane is a rigid linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates targeted protein degradation, exemplified by its application in creating potent IRAK4 PROTAC degraders, such as FIP22, which demonstrate efficacy in conditions like atopic dermatitis. Its structural characteristics enhance the stability and specificity of PROTAC development, making it a valuable tool in chemical biology research.
Chemical Information
| Catalog Num | A82165 |
|---|---|
| M. Wt | 182.31 |
| Formula | C11H22N2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 93004-48-9 |
| Synonyms | |
| SMILES | CN(CC1)CCC21CCN(C)CC2 |
Biological Activity
| Description | 3,9-Dimethyl-3,9-diazaspiro[5.5]undecane is a rigid linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates targeted protein degradation, exemplified by its application in creating potent IRAK4 PROTAC degraders, such as FIP22, which demonstrate efficacy in conditions like atopic dermatitis. Its structural characteristics enhance the stability and specificity of PROTAC development, making it a valuable tool in chemical biology research. |
|---|
RETURN POLICY
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
